|
KMID : 1140120120170020163
|
|
Cancer Prevention Research
2012 Volume.17 No. 2 p.163 ~ p.168
|
|
|
Antitumor Efficacy of Albizzia julibrissin Extract on Sarcoma Induced in Mouse
|
|
Kim Ji-Hyun
Han Chang-Hee
Lee Jong-Hwan
Kim Kwang-Hyeon
|
|
|
Abstract
|
|
|
|
This study was aimed at the possibility as an anti-tumor agent of a triterpenoid saponin (HaBC18) extracted from stem bark of Albizzia julibrissin in vivo. In order to evaluate anti-tumor activity of the HaBC18 in vivo, a tumor in the right side femoral muscle of Balb/c mouse was established by sarcoma 180 cells. The mouse bearing the tumor was orally medicated with the HaBC18, 4 times at a week interval. Compared to those of control groups bearing acites without agent treatment, the increased life span (ILS) of mouse bearing acites treated with the HaBC18 was 136.8% and the tumor inhibition ratio (TIR) of mouse bearing sarcoma was 39.0%. Apoptosis of the tumor cells in mice treated with HaBC18 were also observed by TUNEL assay. In conclusion, the HaBC18 has anti-tumor activity against the tumor induced by sarcoma 180 cells in mouse.
|
|
|
KEYWORD
|
|
|
Albizzia julibrissin, Julibroside, Anti-tumor, TUNEL assay, In vivo
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|